Dimethylamine → HCID 59753757, compound

Participants

Reaction Steps

To a solution of 1.67 g of the compound obtained in Step 85-1 in a mixed solution of MeOH and THF (25 ml 4:1; v/v) was added a solution of 2 mol/L dimethylamine in MeOH (6.0 ml) and the reaction solution was stirred at room temperature for 24 hours. The reaction solution was concentrated under vacuum, the obtained residue was purified by column chromatography (silicagel 60; mobile phase: CHCl3/MeOH=9/1 to 5/1; v/v, 0.1% NH4OH content) to obtain 0.66 g of the title compound (brown oil).

Provenance & Evidence