3,5-Dichloro-3-(2-methoxyphenyl)indolin-2-one → HCID 67428603, compound

HRID 1662678Notes

Reaction equation

HRID 1662678 reaction equation
Cl[C:2]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[NH:4][C:3]1=[O:12].[NH2:21][C@@H:22]([CH2:28][C:29]1[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=1)[C:23]([N:25]([CH3:27])[CH3:26])=[O:24]>>[Cl:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][C:3](=[O:12])[C:2]2([NH:21][C@@H:22]([CH2:28][C:29]1[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=1)[C:23]([N:25]([CH3:27])[CH3:26])=[O:24])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH3:20]

Participants

3

Reactant 2

HCID 219059133,5-Dichloro-3-(2-methoxyphenyl)indolin-2-oneHCID 59753757HCID 59753757, compound

Product 1

HCID 67428603HCID 67428603, compound

Procedure

With 1.82 g of 3,5-dichloro-3-(2-methoxyphenyl)-1,3-dihydro-2H-indol-2-one and 0.61 g of the compound obtained in Step 85-2 as starting materials, 246 mg (Isomer A, yellow amorphous) and 536 mg (Isomer B, pale yellow amorphous) of the respective diastereoisomers of the title compound were obtained by a similar method to Step 4-2.

Sources & evidence

ORD record
ord-4a67ee1016234f55bb6a822f3912c586
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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