Benzyl Bromide → HCID 131729222, compound

Participants

Reaction Steps

A solution of 2.62 g of the compound obtained in Step 86-1 in DMF (30 ml) was added sequentially 1.29 g of K2CO3 and benzyl bromide (1.1 ml), and the reaction mixture was stirred at room temperature for 3 hours. The solution was cooled on ice, then, a saturated aqueous solution of NaHCO3 was added, and the mixture was extracted with EtOAc. The combined organic layer was washed with water and saturated brine, dried over MgSO4, then, the drying agent was separated by filtration and the solvent was evaporated under reduced pressure. The obtained residue was purified by column chromatography (silicagel 60; mobile phase: n-hexane/EtOAc=1/1; v/v) to obtain 2.36 g of the title compound (colorless oil).

Provenance & Evidence