3,5-Dichloro-3-(2-methoxyphenyl)indolin-2-one → HCID 67429746, compound

HRID 1662681Notes

Reaction equation

HRID 1662681 reaction equation
Cl[C:2]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[NH:4][C:3]1=[O:12].FC(F)(F)C(O)=O.[NH2:28][C@@H:29]([CH2:35][C:36]1[CH:41]=[CH:40][C:39]([O:42][CH2:43][C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)=[CH:38][CH:37]=1)[C:30]([N:32]([CH3:34])[CH3:33])=[O:31]>>[CH2:43]([O:42][C:39]1[CH:40]=[CH:41][C:36]([CH2:35][C@H:29]([NH:28][C:2]2([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[O:19][CH3:20])[C:10]3[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=3)[NH:4][C:3]2=[O:12])[C:30]([N:32]([CH3:34])[CH3:33])=[O:31])=[CH:37][CH:38]=1)[C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1

Participants

3

Reactant 2

HCID 219059133,5-Dichloro-3-(2-methoxyphenyl)indolin-2-oneHCID 67429183HCID 67429183, compound

Product 1

HCID 67429746HCID 67429746, compound

Procedure

With 4.58 g of 3,5-dichloro-3-(2-methoxyphenyl)-1,3-dihydro-2H-indol-2-one and the compound obtained in Step 86-3 (5.02 mmol, crude form) as starting materials, 1.09 g (Isomer A, yellow solid) and 1.67 g (Isomer B, colorless amorphous) of the respective diastereoisomers of the title compound were obtained by a similar method to Step 4-2.

Sources & evidence

ORD record
ord-ec8cae3793d2469590826f879ad33289
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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