HCID 11263835, compound → HCID 67430352, compound

HRID 1662683Notes

Reaction equation

HRID 1662683 reaction equation
Cl[C:2]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[NH:4][C:3]1=[O:12].[NH2:21][C@@H:22]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[C:23]([N:25]([CH3:27])[CH3:26])=[O:24]>>[Cl:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][C:3](=[O:12])[C:2]2([NH:21][C@@H:22]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[C:23]([N:25]([CH3:27])[CH3:26])=[O:24])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH3:20]

Participants

3

Reactant 2

HCID 11263835HCID 11263835, compoundHCID 219059133,5-Dichloro-3-(2-methoxyphenyl)indolin-2-one

Product 1

HCID 67430352HCID 67430352, compound

Procedure

With 1.45 g of 3,5-dichloro-3-(2-methoxyphenyl)-1,3-dihydro-2H-indol-2-one and 0.92 g of the compound obtained in Step 87-2 (5.16 mmol, crude form) as starting materials, 1.09 g (Isomer A, colorless amorphous) and 1.31 g (Isomer B, colorless amorphous) of the respective diastereoisomers of the title compound were obtained by a similar method to Step 4-2.

Sources & evidence

ORD record
ord-b4d69ce640d74f259aaf1c7862f747f8
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

Loading…