HCID 67429650, compound → HCID 11952338, compound

HRID 1662686Notes

Reaction equation

HRID 1662686 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([C:10]3([N:23]4[CH2:32][C@H:31]([OH:33])[CH2:30][C@H:24]4[C:25]([N:27]([CH3:29])[CH3:28])=[O:26])[C:18]4[C:13](=[CH:14][CH:15]=[C:16]([N+:19]([O-:21])=[O:20])[CH:17]=4)[NH:12][C:11]3=[O:22])[C:4]=2[O:3][CH2:2]1.[CH3:34][O:35][C:36]1[CH:41]=[CH:40][C:39]([S:42](Cl)(=[O:44])=[O:43])=[C:38]([O:46][C:47]([F:50])([F:49])[F:48])[CH:37]=1>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([C:10]3([N:23]4[CH2:32][C@H:31]([OH:33])[CH2:30][C@H:24]4[C:25]([N:27]([CH3:29])[CH3:28])=[O:26])[C:18]4[C:13](=[CH:14][CH:15]=[C:16]([N+:19]([O-:21])=[O:20])[CH:17]=4)[N:12]([S:42]([C:39]4[CH:40]=[CH:41][C:36]([O:35][CH3:34])=[CH:37][C:38]=4[O:46][C:47]([F:48])([F:49])[F:50])(=[O:44])=[O:43])[C:11]3=[O:22])[C:4]=2[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 67429650HCID 67429650, compoundHCID 866256844-Methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride

Product 1

HCID 11952338HCID 11952338, compoundYield 37.5%

Procedure

With 279 mg of the compound obtained in Step 94-2 (Isomer B) and 214 mg of 4-methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride as starting materials, 163 mg of the title compound (pale yellow solid) was obtained by a similar method to Example 2.

Sources & evidence

ORD record
ord-6bf40513f1e64c5a827d57dcb0594c5e
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

Loading…