HCID 67430202, compound → HCID 67428680, compound

HRID 1662698Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2([N:21]1[CH2:26][CH2:25][N:24]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:23][CH:22]1[C:34]([N:36]([CH3:38])[CH3:37])=[O:35])[C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[O:19][CH3:20].[CH3:39][O:40][C:41]1[CH:46]=[CH:45][C:44]([S:47](Cl)(=[O:49])=[O:48])=[C:43]([O:51][C:52]([F:55])([F:54])[F:53])[CH:42]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:47]([C:44]1[CH:45]=[CH:46][C:41]([O:40][CH3:39])=[CH:42][C:43]=1[O:51][C:52]([F:53])([F:54])[F:55])(=[O:49])=[O:48])[C:6](=[O:11])[C:5]2([N:21]1[CH2:26][CH2:25][N:24]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:23][CH:22]1[C:34]([N:36]([CH3:38])[CH3:37])=[O:35])[C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[O:19][CH3:20]

Participants

Reactant 2

HCID 67430202HCID 67430202, compound

HCID 866256844-Methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride

Product 1

HCID 67428680HCID 67428680, compoundYield 80.5%

Procedure

With 1.70 g of the compound obtained in Step 109-5 and 1.00 g of 4-methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride as starting material, 2.01 g of the title compound (amorphous) was obtained by a similar procedure to Example 2.

Sources & evidence

ORD record: ord-e9f8e07a9f564a2f935aff148bba669a
Source dataset: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08030499B2

Reaction notes

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