3,5-Dichloro-3-(2-methoxyphenyl)indolin-2-one → HCID 86625710, compound

HRID 1662699Notes

Reaction equation

HRID 1662699 reaction equation
Cl[C:2]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[NH:4][C:3]1=[O:12].Cl.C([N:29]1[CH2:34][CH2:33][CH2:32][CH2:31][C@H:30]1[C:35]([OH:37])=[O:36])C1C=CC=CC=1>>[Cl:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][C:3](=[O:12])[C:2]2([N:29]1[CH2:34][CH2:33][CH2:32][CH2:31][C@H:30]1[C:35]([O:37][CH2:2][C:10]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1)=[O:36])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH3:20]

Participants

3

Reactant 2

HCID 219059133,5-Dichloro-3-(2-methoxyphenyl)indolin-2-oneHCID 67430371HCID 67430371, compound

Product 1

HCID 86625710HCID 86625710, compoundYield 202.9%

Procedure

With 2.19 g of 3,5-dichloro-3-(2-methoxyphenyl)-1,3-dihydro-2H-indol-2-one and 2.00 g of benzyl(2S)piperidine-2-carboxylic acid hydrochloride, which is the compound described in Example X of the brochure Publication No. WO98/42342, as starting materials, 3.54 g of the title compound (amorphous) was obtained by a similar method to Step 4-2.

Sources & evidence

ORD record
ord-87a3e497a83a43cb8eb5623f37311352
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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