HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-4-methylanisole → 5-chloro-3-hydroxy-3-(2-methoxy-5-methylphenyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-4-methylanisole | HCID 89143 | — |
| Reactant | 5-chloro-1H-pyrrolo[2,3-b]pyridine-2,3-dione | HCID 67430535 | — |
| Product | 5-chloro-3-hydroxy-3-(2-methoxy-5-methylphenyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one | HCID 67430181 | 81.9% |
Reaction Steps
With 1.49 g of 2-bromo-4-methyl anisole and 900 mg of the compound obtained in Step 118-4 as starting materials, 1.23 g of the title compound (brown solid) was obtained by a similar method to Step 21-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030499B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-8e71cc0f4c8545c184221b8d1d01a314 |
| Source note | uspto-grants-2011_10 |