5-chloro-3-hydroxy-3-(2-methoxy-5-methylphenyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one → 5-chloro-3-hydroxy-3-(2-methoxy-5-methylphenyl)-1-{[4-methoxy-2-(trifluoromethoxy)phenyl]sulfonyl}-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one

Participants

Reaction Steps

With 1.18 g of the compound obtained in Step 118-5 and 1.24 g of 4-methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride as starting materials, 565 mg of the title compound (brown gummy substance) was obtained by a similar method to Example 2.

Provenance & Evidence