HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-4-methylanisole → 3-Hydroxy-3-(2-methoxy-5-methylphenyl)-2-oxo indoline-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-4-methylanisole | HCID 89143 | — |
| Reactant | 2,3-Dioxo-2,3-dihydro-1H-indole-5-carbonitrile | HCID 12351495 | — |
| Product | 3-Hydroxy-3-(2-methoxy-5-methylphenyl)-2-oxo indoline-5-carbonitrile | HCID 67429126 | 50.8% |
Reaction Steps
With 7.06 g of 2-bromo-1-methoxy-4-methyl benzene and 4.03 g of 2,3-dioxo indoline-5-carbonitrile as starting materials, 3.50 g of the title compound (brown amorphous) was obtained by a similar method to Step 21-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030499B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-be3b397b6f844ecabd11d3434e4bb9c9 |
| Source note | uspto-grants-2011_10 |