HCID 67430123, compound → HCID 59867839, compound

HRID 1662710Notes

Reaction equation

HRID 1662710 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2([N:21]1[CH2:30][C@H:29]([OH:31])[CH2:28][C@@H:22]1[C:23]([N:25]([CH3:27])[CH3:26])=[O:24])[C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[O:19][CH3:20].[CH3:32][O:33][C:34]1[CH:39]=[CH:38][C:37]([S:40](Cl)(=[O:42])=[O:41])=[C:36]([O:44][C:45]([F:48])([F:47])[F:46])[CH:35]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:40]([C:37]1[CH:38]=[CH:39][C:34]([O:33][CH3:32])=[CH:35][C:36]=1[O:44][C:45]([F:46])([F:47])[F:48])(=[O:42])=[O:41])[C:6](=[O:11])[C:5]2([N:21]1[CH2:30][C@H:29]([OH:31])[CH2:28][C@@H:22]1[C:23]([N:25]([CH3:27])[CH3:26])=[O:24])[C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[O:19][CH3:20]

Participants

3

Reactant 2

HCID 67430123HCID 67430123, compoundHCID 866256844-Methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride

Product 1

HCID 59867839HCID 59867839, compound

Procedure

With 700 mg of the compound obtained in Step 133-1 and 505 mg of 4-methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride as starting materials, respectively 219 mg (Isomer A: colorless amorphous) and 314 mg (Isomer B: colorless amorphous) of two species of diastereoisomers of the title compound were obtained by a similar method to Example 2.

Sources & evidence

ORD record
ord-99334374cd7b4a21a576b15faba72d76
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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