HCID 67430144, compound → HCID 59867813, compound

HRID 1662712Notes

Reaction equation

HRID 1662712 reaction equation
[C:1]([O:4][C@@H:5]1[CH2:9][C@@H:8]([C:10]([N:12]([CH3:14])[CH3:13])=[O:11])[N:7]([C:15]2([C:26]3[CH:31]=[C:30]([CH3:32])[CH:29]=[CH:28][C:27]=3[O:33][CH3:34])[C:23]3[C:18](=[CH:19][CH:20]=[C:21]([Cl:24])[CH:22]=3)[NH:17][C:16]2=[O:25])[CH2:6]1)(=[O:3])[CH3:2].[CH3:35][O:36][C:37]1[CH:42]=[CH:41][C:40]([S:43](Cl)(=[O:45])=[O:44])=[C:39]([O:47][C:48]([F:51])([F:50])[F:49])[CH:38]=1>>[C:1]([O:4][C@@H:5]1[CH2:9][C@@H:8]([C:10]([N:12]([CH3:14])[CH3:13])=[O:11])[N:7]([C:15]2([C:26]3[CH:31]=[C:30]([CH3:32])[CH:29]=[CH:28][C:27]=3[O:33][CH3:34])[C:23]3[C:18](=[CH:19][CH:20]=[C:21]([Cl:24])[CH:22]=3)[N:17]([S:43]([C:40]3[CH:41]=[CH:42][C:37]([O:36][CH3:35])=[CH:38][C:39]=3[O:47][C:48]([F:49])([F:50])[F:51])(=[O:45])=[O:44])[C:16]2=[O:25])[CH2:6]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 67430144HCID 67430144, compoundHCID 866256844-Methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride

Product 1

HCID 59867813HCID 59867813, compoundYield 69.1%

Procedure

With 500 mg of the compound obtained in Step 137-3 (Isomer B) and 329 mg of 4-methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride as starting materials, 526 mg of the title compound (colorless amorphous) was obtained by a similar method to Example 2.

Sources & evidence

ORD record
ord-48f8ab968b384c4eabc0ecc8157150ce
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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