HCID 67429294, compound → HCID 59867930, compound

HRID 1662716Notes

Reaction equation

HRID 1662716 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2([N:21]1[CH2:30][C@H:29]([O:31][CH2:32][CH2:33][OH:34])[CH2:28][C@H:22]1[C:23]([N:25]([CH3:27])[CH3:26])=[O:24])[C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[O:19][CH3:20].[CH3:35][O:36][C:37]1[CH:42]=[CH:41][C:40]([S:43](Cl)(=[O:45])=[O:44])=[C:39]([O:47][C:48]([F:51])([F:50])[F:49])[CH:38]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:43]([C:40]1[CH:41]=[CH:42][C:37]([O:36][CH3:35])=[CH:38][C:39]=1[O:47][C:48]([F:49])([F:50])[F:51])(=[O:45])=[O:44])[C:6](=[O:11])[C:5]2([N:21]1[CH2:30][C@H:29]([O:31][CH2:32][CH2:33][OH:34])[CH2:28][C@H:22]1[C:23]([N:25]([CH3:27])[CH3:26])=[O:24])[C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[O:19][CH3:20]

Participants

3

Reactant 2

HCID 67429294HCID 67429294, compoundHCID 866256844-Methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride

Product 1

HCID 59867930HCID 59867930, compoundYield 4.3%

Procedure

With 750 mg of the compound obtained in Step 141-4 and 491 mg of 4-methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride as starting material, 49 mg of the title compound (amorphous) was obtained by a similar procedure to Example 2. [α]D25=−113° (c=0.150, CHCl3)

Sources & evidence

ORD record
ord-b514b8bd326545148b86c07f2a43a7f9
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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