4-Methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride → HCID 59867873, compound

HRID 1662724Notes

Reaction equation

HRID 1662724 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2([N:21]1[CH2:35][C@H:34]([OH:36])[CH2:33][C@H:22]1[C:23]([O:25][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)=[O:24])[C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[O:19][CH3:20].[CH3:37][O:38][C:39]1[CH:44]=[CH:43][C:42]([S:45](Cl)(=[O:47])=[O:46])=[C:41]([O:49][C:50]([F:53])([F:52])[F:51])[CH:40]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:45]([C:42]1[CH:43]=[CH:44][C:39]([O:38][CH3:37])=[CH:40][C:41]=1[O:49][C:50]([F:51])([F:52])[F:53])(=[O:47])=[O:46])[C:6](=[O:11])[C:5]2([N:21]1[CH2:35][C@H:34]([OH:36])[CH2:33][C@H:22]1[C:23]([O:25][CH2:26][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)=[O:24])[C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[O:19][CH3:20]

Participants

3

Reactant 2

HCID 866256844-Methoxy-2-(trifluoromethoxy)benzene sulfonyl chlorideHCID 91457211HCID 91457211, compound

Product 1

HCID 59867873HCID 59867873, compoundYield 71.7%

Procedure

With 2.6 g of the compound obtained in Step 157-3 (Isomer B) and 1.79 g of 4-methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride as starting materials, 2.8 g of the title compound (colorless amorphous) was obtained by a similar method to Example 2.

Sources & evidence

ORD record
ord-2c6a4bbdab674db4b3d11bdf60ec802e
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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