HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-chloro-1H-indole-2,3-dione → 5-chloro-3-hydroxy-3-(2-methoxy-5-morpholin-4-ylphenyl)-1,3-dihydro-2H-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-chloro-1H-indole-2,3-dione | HCID 87203 | — |
| Reactant | 4-(3-Bromo-4-methoxyphenyl)morpholine | HCID 67429791 | — |
| Product | 5-chloro-3-hydroxy-3-(2-methoxy-5-morpholin-4-ylphenyl)-1,3-dihydro-2H-indol-2-one | HCID 67428909 | 77.3% |
Reaction Steps
With 2.00 g of the compound obtained in Step 191-1 and 953 mg of 5-chloroisatin as starting materials, 1.52 g of the title compound (pale yellow amorphous) was obtained by a similar method to Step 21-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030499B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-4295049017c74788805de3e2f81f0b14 |
| Source note | uspto-grants-2011_10 |