(4R)-4-hydroxy-N,N-dimethyl-L-prolinamide trifluoroacetate → HCID 67429124, compound

HRID 1662739Notes

Reaction equation

HRID 1662739 reaction equation
Cl[C:2]1([C:13]2[CH:18]=[C:17]([N:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)[CH:16]=[CH:15][C:14]=2[O:25][CH3:26])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[NH:4][C:3]1=[O:12].FC(F)(F)C(O)=O.[OH:34][C@H:35]1[CH2:39][NH:38][C@H:37]([C:40]([N:42]([CH3:44])[CH3:43])=[O:41])[CH2:36]1>>[Cl:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][C:3](=[O:12])[C:2]2([N:38]1[CH2:39][C@H:35]([OH:34])[CH2:36][C@H:37]1[C:40]([N:42]([CH3:44])[CH3:43])=[O:41])[C:13]1[CH:18]=[C:17]([N:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[CH:16]=[CH:15][C:14]=1[O:25][CH3:26]

Participants

3

Reactant 2

HCID 67429482(4R)-4-hydroxy-N,N-dimethyl-L-prolinamide trifluoroacetateHCID 67430124HCID 67430124, compound

Product 1

HCID 67429124HCID 67429124, compound

Procedure

With 1.10 g of the compound obtained in Step 193-3 and (4R)-4-hydroxy-N,N-dimethyl-L-prolinamide trifluoroacetate (1.83 mmol) as starting materials, respectively 202 mg (Isomer A, brown amorphous) and 343 mg (Isomer B, brown amorphous) of two species of diastereoisomers of the title compound were obtained by a similar procedure to Step 4-2.

Sources & evidence

ORD record
ord-35695fbe5d7b4ce78bd50a03e457cb0e
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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