4-Methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride → HCID 59867892, compound

HRID 1662746Notes

Reaction equation

HRID 1662746 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2([N:22]1[CH2:31][C@H:30]([OH:32])[CH2:29][C@H:23]1[C:24]([N:26]([CH3:28])[CH3:27])=[O:25])[C:12]1[CH:17]=[C:16]([CH:18]=[O:19])[CH:15]=[CH:14][C:13]=1[O:20][CH3:21].[CH3:33][O:34][C:35]1[CH:40]=[CH:39][C:38]([S:41](Cl)(=[O:43])=[O:42])=[C:37]([O:45][C:46]([F:49])([F:48])[F:47])[CH:36]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:41]([C:38]1[CH:39]=[CH:40][C:35]([O:34][CH3:33])=[CH:36][C:37]=1[O:45][C:46]([F:47])([F:48])[F:49])(=[O:43])=[O:42])[C:6](=[O:11])[C:5]2([N:22]1[CH2:31][C@H:30]([OH:32])[CH2:29][C@H:23]1[C:24]([N:26]([CH3:28])[CH3:27])=[O:25])[C:12]1[CH:17]=[C:16]([CH:18]=[O:19])[CH:15]=[CH:14][C:13]=1[O:20][CH3:21]

Participants

3

Reactant 2

HCID 866256844-Methoxy-2-(trifluoromethoxy)benzene sulfonyl chlorideHCID 86625716HCID 86625716, compound

Product 1

HCID 59867892HCID 59867892, compound

Procedure

With 10.9 g of the compound obtained in Step 198-2 and 6.63 g of 4-methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride as starting materials, 6.76 g of a mixture of two species of diastereoisomers of the title compound (colorless amorphous) was obtained by a similar method to Example 2.

Sources & evidence

ORD record
ord-bf022673c77845578ef0e067fe0513f1
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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