HCID 67429103, compound → HCID 67428549, compound

HRID 1662751Notes

Reaction equation

HRID 1662751 reaction equation
[Si:1]([O:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([O:28][CH3:29])=[C:14]([C:16]2(O)[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([Cl:25])[CH:23]=3)[NH:18][C:17]2=[O:26])[CH:15]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].FC(F)(F)C(O)=O.[OH:37][C@H:38]1[CH2:42][NH:41][C@H:40]([C:43]([N:45]([CH3:47])[CH3:46])=[O:44])[CH2:39]1>>[Si:1]([O:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([O:28][CH3:29])=[C:14]([C:16]2([N:41]3[CH2:42][C@H:38]([OH:37])[CH2:39][C@H:40]3[C:43]([N:45]([CH3:47])[CH3:46])=[O:44])[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([Cl:25])[CH:23]=3)[NH:18][C:17]2=[O:26])[CH:15]=1)([C:4]([CH3:5])([CH3:6])[CH3:7])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 67429103HCID 67429103, compoundHCID 67429482(4R)-4-hydroxy-N,N-dimethyl-L-prolinamide trifluoroacetate

Product 1

HCID 67428549HCID 67428549, compound

Procedure

With 50.0 g of the compound obtained in Step 204-3 and (4R)-4-hydroxy-N,N-dimethyl-L-prolinamide trifluoroacetate (138 mmol) as starting materials, respectively 5.25 g (Isomer A: colorless amorphous) and 14.9 g (Isomer B: colorless amorphous) of two species of diastereoisomers of the title compound and a mixture of isomers A and B (11.0 g) were obtained by a similar method to Step 28-2.

Sources & evidence

ORD record
ord-58a93e0549ea4a6bba87d573ed7b0cef
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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