Dimethylamine → (4R)-1-(5-chloro-3-{5-[2-(dimethylamino)ethyl]-2-methoxyphenyl}-1-{[4-methoxy-2-(trifluoro methoxy)phenyl]sulfonyl}-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-L-prolin amide

Participants

Reaction Steps

With 500 mg of the compound obtained in Example 219, a solution of 2 mol/L dimethylamine in THF (0.76 ml) as starting material, 300 mg of the title compound (light yellow amorphous) was obtained by a similar method to Example 220.

Provenance & Evidence