HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → (4R)-1-(5-chloro-3-[2-methoxy-5-(2-morpholin-4-ylethyl)phenyl]-1-{[4-methoxy-2-(trifluoromethoxy)phenyl]sulfonyl}-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-L-prolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | HCID 59867806 | HCID 59867806 | — |
| Product | (4R)-1-(5-chloro-3-[2-methoxy-5-(2-morpholin-4-ylethyl)phenyl]-1-{[4-methoxy-2-(trifluoromethoxy)phenyl]sulfonyl}-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-L-prolinamide | HCID 59867961 | — |
Reaction Steps
With 500 mg of the compound obtained in Example 219 and morpholine (0.13 ml) as starting material, 300 mg of the title compound (colorless amorphous) was obtained by a similar method to Example 220.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030499B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-4fba8240956b4248b25363ac88de9d77 |
| Source note | uspto-grants-2011_10 |