HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → (4R)-1-(5-chloro-3-{2-methoxy-5-[2-(4-methylpiperazin-1-yl)ethyl]phenyl}-1-{[4-methoxy-2-(tr ifluoromethoxy)phenyl]sulfonyl}-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-L-prolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | HCID 59867806 | HCID 59867806 | — |
| Product | (4R)-1-(5-chloro-3-{2-methoxy-5-[2-(4-methylpiperazin-1-yl)ethyl]phenyl}-1-{[4-methoxy-2-(tr ifluoromethoxy)phenyl]sulfonyl}-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-L-prolinamide | HCID 59867814 | — |
Reaction Steps
With 500 mg of the compound obtained in Example 219 and 1-methylpiperazine (0.17 ml) as starting material, 287 mg of the title compound (light yellow amorphous) was obtained by a similar method to Example 220.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030499B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-c14c424d5ab2400980425f012ac535af |
| Source note | uspto-grants-2011_10 |