HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → (4R)-1-(5-chloro-3-[2-methoxy-5-(2-pyrrolidin-1-ylethyl)phenyl]-1-{[4-methoxy-2-(trifluoromethoxy)phenyl]sulfonyl}-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-L-prolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | HCID 59867806 | HCID 59867806 | — |
| Product | (4R)-1-(5-chloro-3-[2-methoxy-5-(2-pyrrolidin-1-ylethyl)phenyl]-1-{[4-methoxy-2-(trifluoromethoxy)phenyl]sulfonyl}-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-L-prolinamide | HCID 59867859 | 29.2% |
Reaction Steps
With 350 mg of the compound obtained in Example 219 and 75 mg of pyrrolidine as starting materials, 110 mg of the title compound (pale orange amorphous) was obtained by a similar method to Example 220.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030499B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-7ecede1a691944f4a8acdca0fe10d291 |
| Source note | uspto-grants-2011_10 |