tert-Butyl piperazine-1-carboxylate → tert-butyl 4-{2-[3-(5-chloro-3-{(2S,4R)-2-[(dimethylamino)carbonyl]-4-hydroxypyrrolidin-1-yl}-1-{[4-methoxy-2-(trifluoromethoxy)phenyl]sulfonyl}-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-methoxyphenyl]ethyl}piperazine-1-carboxylate

Participants

Reaction Steps

With 2.00 g of the compound obtained in Example 219 and 3.3 g of piperazine-1-carboxylic acid tert-butyl ester as starting materials, 120 mg of the title compound (colorless oil) was obtained by a similar procedure to Example 227.

Provenance & Evidence