HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-chloro-1H-indole-2,3-dione → 3-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-methoxyphenyl]-5-chloro-3-hydroxy-1,3-dihydro-2H-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-chloro-1H-indole-2,3-dione | HCID 87203 | — |
| Reactant | ((4-Bromo-3-methoxybenzyl)oxy)(tert-butyl)dimethylsilane | HCID 67429327 | — |
| Product | 3-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-methoxyphenyl]-5-chloro-3-hydroxy-1,3-dihydro-2H-indol-2-one | HCID 67429824 | 21.6% |
Reaction Steps
With 6.99 g of the compound obtained in Step 237-2 and 3.21 g of 5-chloroisatin as starting materials, 1.66 g of the title compound (colorless solid) was obtained by a similar method to Step 21-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030499B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-17731c54dcf24c59adb87a96d5be2d94 |
| Source note | uspto-grants-2011_10 |