HRID1662773

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CN(C)C(=O)[C@@H]1C[C@@H](O)CN1.O=C(O)C(F)(F)F

HCID67429482

未命名化合物

结构：COc1cc(CO[Si](C)(C)C(C)(C)C)ccc1C1(O)C(=O)Nc2ccc(Cl)cc21

HCID67429824

未命名化合物

PRODUCTS

生成物

结构：COc1cc(CO[Si](C)(C)C(C)(C)C)ccc1C1(N2C[C@H](O)C[C@H]2C(=O)N(C)C)C(=O)Nc2ccc(Cl)cc21

HCID67428574

未命名化合物

PROCEDURE

实验过程

With 1.64 g of the compound obtained in Step 237-3 and (4R)-4-hydroxy-N,N-dimethyl-L-prolinamide trifluoroacetate (5.67 mmol) as starting materials, respectively 901 mg (Isomer A: colorless solid) and 288 mg (Isomer B: colorless amorphous) of two species of diastereoisomers of the title compound were obtained by a similar method to Step 28-2.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c2f48a3c9bd8487e9a7740c088337f5f
来源数据集: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08030499B2
来源说明: uspto-grants-2011_10

反应 SMILES

[Si:1]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2(O)[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([Cl:25])[CH:23]=3)[NH:18][C:17]2=[O:26])=[C:12]([O:28][CH3:29])[CH:11]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].FC(F)(F)C(O)=O.[OH:37][C@H:38]1[CH2:42][NH:41][C@H:40]([C:43]([N:45]([CH3:47])[CH3:46])=[O:44])[CH2:39]1>>[Si:1]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2([N:41]3[CH2:42][C@H:38]([OH:37])[CH2:39][C@H:40]3[C:43]([N:45]([CH3:47])[CH3:46])=[O:44])[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([Cl:25])[CH:23]=3)[NH:18][C:17]2=[O:26])=[C:12]([O:28][CH3:29])[CH:11]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]