Sodium Hydroxide → HCID 59867777, compound

Participants

Reaction Steps

A solution of 5 mg of NaBH4 in TFA (1 ml) was stirred for 15 minutes at room temperature, then, a solution of 28.1 mg of the compound obtained in Example 249 in TFA (3 ml) was added dropwise over 10 minutes. Two hours later, the solution was diluted with water, neutralized with NaOH, and the resulting mixture was extracted with CHCl3. The organic layer was washed with water and with saturated brine and dried over MgSO4, then, the drying agent was separated by filtration and the solvent was evaporated under reduced pressure. The obtained residue was purified by column chromatography (silicagel 60; mobile phase: MeOH/CHCl3=2/98; v/v) to obtain 25.3 mg of the title compound (colorless amorphous).

Provenance & Evidence