3,5-Dichloro-3-(2-methoxyphenyl)indolin-2-one → HCID 67429769, compound

HRID 1662785Notes

Reaction equation

HRID 1662785 reaction equation
Cl[C:2]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[NH:4][C:3]1=[O:12].[CH3:21][N:22]([CH3:35])[C:23](=[O:34])[C@@H:24]([NH:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=1)[CH3:25]>>[Cl:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][C:3](=[O:12])[C:2]2([N:26]([CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=1)[C@@H:24]([CH3:25])[C:23]([N:22]([CH3:35])[CH3:21])=[O:34])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH3:20]

Participants

3

Reactant 2

HCID 219059133,5-Dichloro-3-(2-methoxyphenyl)indolin-2-oneHCID 28835136HCID 28835136, compound

Product 1

HCID 67429769HCID 67429769, compound

Procedure

With 789 mg of 3,5-dichloro-3-(2-methoxyphenyl)-1,3-dihydro-2H-indol-2-one and the compound obtained in Step 253-2 (2.56 mmol, crude form) as starting materials, respectively 821 mg (Isomer A, colorless amorphous) and 406 mg (Isomer B, colorless amorphous) of two species of diastereoisomers of the title compound were obtained by a similar method to Step 4-2.

Sources & evidence

ORD record
ord-dd13fc4ef1df4afb850f5fa65b569cbe
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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