3,5-Dichloro-3-(2-methoxyphenyl)indolin-2-one → HCID 86625722, compound

HRID 1662787Notes

Reaction equation

HRID 1662787 reaction equation
Cl[C:2]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[NH:4][C:3]1=[O:12].FC(F)(F)C(O)=O.[NH2:28][C@@H:29]([CH3:36])[C:30]([N:32]([O:34][CH3:35])[CH3:33])=[O:31]>>[Cl:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][C:3](=[O:12])[C:2]2([NH:28][C@@H:29]([CH3:36])[C:30]([N:32]([O:34][CH3:35])[CH3:33])=[O:31])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH3:20]

Participants

3

Reactant 2

HCID 219059133,5-Dichloro-3-(2-methoxyphenyl)indolin-2-oneHCID 86625723905105-68-2

Product 1

HCID 86625722HCID 86625722, compound

Procedure

With 1.21 g of 3,5-dichloro-3-(2-methoxyphenyl)-1,3-dihydro-2H-indol-2-one and the compound obtained in Step 254-2 (4.31 mmol, crude form) as starting materials, respectively 946 mg (Isomer A, colorless amorphous) and 686 mg (Isomer B, colorless amorphous) of two species of diastereoisomers of the title compound were obtained by a similar method to Step 4-2.

Sources & evidence

ORD record
ord-b2105e2872624f87b2cc2e1464109e37
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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