3,5-Dichloro-3-(2-methoxyphenyl)indolin-2-one → HCID 67427821, compound

HRID 1662792Notes

Reaction equation

HRID 1662792 reaction equation
Cl[C:2]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[NH:4][C:3]1=[O:12].[CH2:21]([NH:28][C@@H:29]([CH3:35])[C:30]([N:32]([CH3:34])[CH3:33])=[O:31])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[CH2:21]([N:28]([C:2]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[NH:4][C:3]1=[O:12])[C@@H:29]([CH3:35])[C:30]([N:32]([CH3:34])[CH3:33])=[O:31])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 219059133,5-Dichloro-3-(2-methoxyphenyl)indolin-2-oneHCID 28834827HCID 28834827, compound

Product 1

HCID 67427821HCID 67427821, compound

Procedure

With 0.95 g of 3,5-dichloro-3-(2-methoxyphenyl)-1,3-dihydro-2H-indol-2-one and the compound obtained in Step 258-2 (3.39 mmol, crude form) as starting materials, respectively 966 mg (Isomer A, colorless amorphous) and 501 mg (Isomer B, colorless amorphous) of two species of diastereoisomers of the title compound were obtained by a similar method to Step 4-2.

Sources & evidence

ORD record
ord-ab36dfdd20454c2b9f676c6b984e9512
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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