HCID 67431241, compound → (4R)-1-(5-chloro-3-[5-(5-hydroxypentyl)-2-methoxyphenyl]-1-{[4-methoxy-2-(trifluoromethoxy)phenyl]sulfonyl}-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-L-prolinamide

Participants

Reaction Steps

Under hydrogen atmosphere, suspension of 200 mg of the compound obtained in Example 262 and 20 mg of 5% palladium-carbon in MeOH (2 ml) was stirred at room temperature for one hour. The insoluble matter was separated by filtration with celite and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (silicagel 60N; mobile phase: CHCl3/MeOH=30/1 to 15/1; v/v) to obtain 86 mg of the title compound (amorphous).

Provenance & Evidence