N-(4-Chloro-3-Hydroxymethyl-Phenyl)-3-Trifluoromethyl-Benzamide → N-(4-Chloro-3-Formyl-Phenyl)-3-Trifluoromethyl-Benzamide

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Reaction Steps

The solution of intermediate 7 (Example 13) (700 mg, 2.1 mmol) and MnO2 (1.8 g, 21 mmol) in anhydrous toluene (30 mL) was refluxed for 2 h. After cooling down, the MnO2 was removed by filtration. The solvent was removed by reduced pressure. The solid was re-crystallized from chloroform to yield an off-white solid (300 mg, 43%).

Provenance & Evidence