5-Amino-2-chlorobenzoic acid → 2-Chloro-5-[(thiophene-2-carbonyl)amino]-benzoic acid

Participants

Reaction Steps

5-Amino-2-chloro-benzoic acid (0.349 g, 2.03 mmol) was diluted with THF (12 mL), treated with thiophene-2-carbonyl chloride (0.240 mL, 2.23 mmol) and stirred overnight. Solvents were then removed and resulting solids were triturated with DCM. After filtration, the title compound was obtained as a white solid (0.5 g, 88%).

Provenance & Evidence