5-Amino-2-chlorobenzoic acid → 2-Chloro-5-(4-Cyano-Benzoylamino)-Benzoic Acid

Participants

Reaction Steps

5-Amino-2-chloro-benzoic acid (0.355 g, 2.06 mmol) was diluted with THF (12 mL), treated with 4-cyano-benzoyl chloride (0.377 g, 2.23 mmol) and stirred for 72 h. Solvents were then removed and resulting solids were triturated with DCM. After filtration, the title compound was obtained as a white solid (0.6 g, 97%).

Provenance & Evidence