HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Anisoyl chloride → 2-Chloro-5-(4-Methoxy-Benzoylamino)-Benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Anisoyl chloride | HCID 7477 | — |
| Reactant | 5-Amino-2-chlorobenzoic acid | HCID 37879 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Chloro-5-(4-Methoxy-Benzoylamino)-Benzoic acid | HCID 28672436 | — |
Reaction Steps
5-Amino-2-chloro-benzoic acid (0.4 g, 2.32 mmol) was diluted with THF (12 mL), treated with 4-methoxy-benzoyl chloride (0.353 g, 2.23 mmol) and stirred for 16 h. Solvents were then removed and resulting solids were triturated with DCM. After filtration, the title compound was obtained as a white solid (0.5 g, 71%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030487B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-91255757119c4f0b904577433143b69e |
| Source note | uspto-grants-2011_10 |