5-Amino-2-chlorobenzoic acid → 2-Chloro-5-(3-Fluoro-Benzoylamino)-Benzoic Acid

Participants

Reaction Steps

5-Amino-2-chloro-benzoic acid (0.96 g, 5.58 mmol) was diluted with THF (60 mL), treated with 3-fluoro-benzoyl chloride (0.738 mL, 6.14 mmol) and stirred for 18 h. Solvents were then removed and resulting solids were triturated with DCM. After filtration, the title compound was obtained as a white solid (1.7 g, 99%).

Provenance & Evidence