4-Methylmorpholine → HCID 59652711, compound

Participants

Reaction Steps

To a suspension of 4-(trifluoromethyl)benzoic acid (1.0 g, 5.3 mmol) in DCM (20 mL) were added CDMT (1.1 g, 6.3 mmol) and NMM (2.3 mL, 21 mmol). The mixture was stirred at RT for 30 min under an argon atmosphere. 5-amino-2-chlorobenzoic acid (1.4 g, 7.9 mmol) was added and the mixture stirred at RT for additional 2 h. The reaction mixture was poured into saturated NaHCO3 solution and then extracted with DCM. The organic layer was dried (Na2SO4), filtered and the filtrate concentrated to afford the title compound (1.6 g, 88%) as a cream solid.

Provenance & Evidence