HCID 58748735, compound → HCID 58748706, compound

Participants

Reaction Steps

Intermediate 44 (Example 92) (4.26 mmol, 1.0 equiv) dissolved in MeOH (0.05-1.0 M) was evacuated of air and placed under an argon blanket; Pd/C (10% by wt) was then added. The mixture was evacuated and then refilled with hydrogen and stirred at room temperature for 4 h. Filtration through CELITE with a MeOH wash, followed by concentration under reduced pressure afford the title compound as a white solid (100 mg, 7%). The crude amino-compound was used in the next step without purification. MS (ES+): m/z=363 (M+H)+. LC retention time: 1.34 min.

Provenance & Evidence