3-(4-Bromophenyl)propionic acid → 3-(4-Bromophenyl)propan-1-ol

Participants

Reaction Steps

To a solution of 3-(4-bromo-phenyl)-propionic acid (4.0 g, 18 mmol) in THF (30 mL) at 0° C. under the argon atmosphere was added LiAlH4 (1.0 M in THF; 14 mL, 14 mmol). After the addition, the ice-bath was removed and the mixture refluxed for 18 h. After cooling to room temperature, the reaction was quenched with 1 M HCl and the mixture extracted with ethyl acetate. The organic layer was separated, washed with brine, dried over Na2SO4 and filtered. The filtrate was concentrated and the crude product used in the next step without further purification.

Provenance & Evidence