2-Chloroquinoline → HCID 59652698, compound

HRID 1662850Notes

Reaction equation

HRID 1662850 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH2:12][C:13]1[CH:14]=[CH:15][C:16]([Cl:22])=[C:17]([CH:21]=1)[C:18]([OH:20])=[O:19]>C(O)(=O)C>[Cl:22][C:16]1[CH:15]=[CH:14][C:13]([NH:12][C:2]2[CH:11]=[CH:10][C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)=[CH:21][C:17]=1[C:18]([OH:20])=[O:19]

Participants

4

Reactant 2

HCID 119282-ChloroquinolineHCID 378795-Amino-2-chlorobenzoic acid

Product 1

HCID 59652698HCID 59652698, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 2-chloro-quinoline (0.50 g, 3.1 mmol) and 5-amino-2-chloro-benzoic acid (0.53 g, 3.1 mmol) in acetic acid (10 mL) was heated at 100° C. for 2 h. Acetic acid was removed and the residue triturated in ethyl acetate. The title compound was obtained as a white solid (0.55 g, 59%) after the filtration. MS (ES+): m/z 299 (M+H)+.

Workup

  1. customAcetic acid was removed
  2. customthe residue triturated in ethyl acetate

Sources & evidence

ORD record
ord-4c3400dcd84f4c9780ab4f0645f4ef69
Source dataset
uspto-grants-2011_10
Patent number
US08030487B2

Reaction notes

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