Potassium Fluoride → HCID 86638406, compound

Participants

Reaction Conditions

Reaction Steps

3,4-bis(diethoxyphosphoryl)-2-iodothiophene, different types of palladium catalysts (0.05 equivalents, commercially available products) indicated in the following Table 5 and commercially available copper(I) cyanide (0.20 equivalents) were dissolved in toluene, to which 2-tributylstannylthiophene (1.2 equivalents) was added at room temperature. Thereafter, the reaction mixture was heated to 70° C. and stirred for 8.5 to 10 hours. After the reaction, the reaction mixture was cooled down to room temperature, to which a potassium fluoride aqueous solution was added, followed by stirring for 2 hours. The resulting solid was removed by celite filtration and the filtrate was extracted with ethyl acetate. The organic phase was washed with a saturated saline solution and dried over anhydrous sodium sulfate. The solvent was removed by distilling off under reduced pressure, and the resulting crude product was purified with a silica gel column (ethyl acetate:methanol=15:1) to obtain the specified substances.

Provenance & Evidence