Hydrochloric Acid → HCID 86638406, compound

Participants

Reaction Conditions

Reaction Steps

3,4-bis(diethoxyphosphoryl)-2-iodothiophene and different equivalents of copper(I) chloride (commercially available product) indicated in Table 6 were dissolved in DMF, to which 2-tributylstannylthiophene (1.2 equivalents) was added at room temperature. Thereafter, the reaction mixture was heated to 80° C. and stirred for 8.5 to 11 hours. After the reaction, the reaction mixture was cooled down to room temperature, to which a 0.6 M hydrochloric acid aqueous solution was added, followed by extraction of the resulting product with ethyl acetate. The organic phase was washed with a saturated saline solution and dried over anhydrous sodium sulfate. The solvent was removed by distilling off under reduced pressure and the resulting crude product was purified with a silica gel column (ethyl acetate:methanol=15:1) to obtain the specified substance.

Provenance & Evidence