HCID 86638407, compound → HCID 86638409, compound

Participants

Reaction Conditions

Reaction Steps

In THF, 0.082 g (0.171 mmols) of the 2-iodo-3,4-bis(diethoxyphosphoryl)thiophene obtained in Example 4 and 0.009 g (0.00775 mmols) of commercially available tetrakistriphenylphosphine palladium, and 0.0014 g (0.0155 mmols) of commercially available copper(I) chloride were dissolved, to which 0.100 g (0.155 mmols) of the 2-tributylstannyl-3,4-bis(diethoxyphosphoryl)thiophene obtained in Example 5 was added at room temperature. Thereafter, the reaction mixture was heated to 70° C. and stirred for 11 hours. After the reaction, the reaction mixture was cooled down to room temperature, followed by distilling off under reduced pressure to remove the solvent, and the resulting crude product was purified with a silica gel column (ethyl acetate:methanol=15:1 to ethyl acetate:methanol=5:1) to obtain the specified substance at a yield of 0.046 g (yield: 38%).

Provenance & Evidence