Hydrochloric Acid → 3',4'-Bis(diethoxyphosphoryl)-[2,2':5',2'']-terthiophene

Participants

Reaction Conditions

Reaction Steps

3,4-bis(diethoxyphosphoryl)-2,5-diiodothiophene obtained in Example 7, and different types of copper reagents (2.2 equivalents, commercial products) indicated in Table 9 were dissolved in DMF, to which 2-tributylstannylthiophene (2.2 equivalents) was added at room temperature. Thereafter, the reaction mixture was heated to 80° C. and stirred for 11 to 13 hours. After the reaction, the reaction mixture was cooled down to room temperature, to which a 0.6 M hydrochloric acid aqueous solution was added, followed by extraction of the resulting product with ethyl acetate. The organic phase was washed with a saturated saline solution and dried over anhydrous sodium sulfate. The solvent was removed by distilling off under reduced pressure, and the resulting product was purified with a silica gel column (ethyl acetate:methanol=15:1) to obtain the specified substance.

Provenance & Evidence