HCID 59155854, compound → HCID 59155811, compound

Participants

Reaction Conditions

Reaction Steps

In THF, 3.10 g (5.9 mmols) of 3-(dibutoxyphosphoryl)-2,5-diiodothiophene was dissolved and cooled down to −78° C. Commercially available n-butyl lithium (1.59 M hexane solution, 6.2 mmols) was slowly dropped, followed by stirring for 1 hour at a standing temperature. Thereafter, a disodium hydrogen phosphate/sodium dihydrogen phosphate buffer solution, adjusted to pH=7, was added, followed by extraction with ethyl acetate. The organic phase was washed with a saturated saline solution and dried over anhydrous sodium sulfate. The solvent was removed by distilling off under reduced pressure, and the resulting crude product was purified with a silica gel column (ethyl acetate:hexane=1:1) to obtain the specified substance in the form of a brown oil at a yield of 1.88 g (yield: 79%). The thus obtained substance was used as it is for reaction in Example 12(18).

Provenance & Evidence