3-Aminopyridine → HCID 178462967, compound

Participants

Reaction Steps

60.2 mg of 3-aminopyridine are solubilized in 0.25 ml of 6N hydrochloric acid. The medium is cooled to zero degrees, and then a solution of 44.2 mg of sodium nitrite in 0.25 ml of water is added over 3 minutes. The medium is then kept stirring for 10 minutes at a temperature of between 0 and 5° C. A mixture of 100 mg of 5-amino-1,2-diethyl-1,2-dihydro-3H-pyrazol-3-one, 0.5 ml of ethanol, 0.5 ml of water and 3 equivalents of sodium acetate is added to the reaction medium.

Provenance & Evidence