Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetramethylammonium hydroxide → Lipoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetramethylammonium hydroxide | HCID 60966 | — |
| 반응물 | (R)-Dihydrolipoic acid | HCID 9834298 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Lipoic acid | HCID 6112 | — |
| 생성물 | (R)-Dihydrolipoic acid | HCID 9834298 | — |
반응 단계
In other synthetic schemes the base, tetramethylammonium hydroxide can be substituted for potassium t-butoxide in DMF. The former base though can be stored under air, whilst the latter needs to be kept in an inert atmosphere. The dihydrolipoic acid works best if it totally clear. If the reduction lipoic acid to produce dihydrolipoic acid is not complete, a yellow coloration of the solution will be evident. The yellow solution can be distilled (distills at 140° C. under vacuum) to yield a clear solution of dihydrolipoic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08034259B2 |
| 출처 데이터셋 | uspto-grants-2011_10 |
| ORD ID | ord-4897e9061e784063a888afb92b4b27f9 |
| 출처 메모 | uspto-grants-2011_10 |