HuagongsheHuagongshe Chemistry Print Report · For research reference only
Quetiapine → Quetiapine fumarate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Quetiapine | HCID 5002 | — |
| Reactant | Fumaric Acid | HCID 444972 | — |
| Solvent | Ethanol, mixt. with methanol | HCID 18681192 | — |
| Product | Quetiapine fumarate | HCID 5281025 | — |
Reaction Steps
In another patent, U.S. Pat. No. 6,372,734, quetiapine hemifumarate is prepared from the crystallized quetiapine base, which is, under boiling, mixed with a solution of fumaric acid in a mixture ethanol/methanol. Crystallized quetiapine hemifumarate is isolated after being cooled to 0° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08034805B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-66664139dd0a47c1bf4e5bd45af07af9 |
| Source note | uspto-grants-2011_10 |