Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Quetiapine | HCID 5002 | — |
| Reactant | Fumaric Acid | HCID 444972 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Quetiapine fumarate | HCID 5281025 | — |
Reaction Steps
A suspension of 1.2 g (0.0103 mol) of fumaric acid in 10 ml of acetone is brought to the boil. 40 ml of a toluene solution containing 7.53 g (0.0196 mol) of pure quetiapine base is added to the boiling suspension. An oily suspension is formed, which crystallizes under boil during 3 to 4 minutes. Reflux is maintained for 5 minutes and then the suspension is cooled to 20° C. and stirred for 60 minutes. Precipitated crystalline quetiapine hemifumarate is isolated by filtration and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08034805B2 |
|---|
| Source dataset | uspto-grants-2011_10 |
|---|
| ORD ID | ord-23dfa716d1b844f8a8bdd435bb908e4f |
|---|
| Source note | uspto-grants-2011_10 |
|---|
