Toluene → Quetiapine fumarate

Participants

Reaction Conditions

Reaction Steps

A suspension of 0.8 g (0.007 mol) of fumaric acid in 120 ml of acetone is brought to the boil. 30 ml of a toluene solution containing 5.06 g (0.0132 mol) of pure quetiapine base is added to the boiling suspension and the reaction mixture is stirred under boil for another 5 minutes. The precipitated crystalline product is cooled to approximately 20° C. and stirred for another 60 minutes. Precipitated crystalline quetiapine hemifumarate is isolated by filtration, washed and dried.

Provenance & Evidence